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KMID : 0191120000150010053
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Journal of Korean Medical Science
2000 Volume.15 No. 1 p.53 ~ p.58
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Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence is not a predictive factor for response to interferon-alpha therapy and development of hepatocellular carcinoma
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Bae SH
Park YM/Yoo DG/Choi JY/Byun BH/Yang JM/Lee CD/Cha SB/Park DH/Kim BS
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Abstract
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Genetic changes between codons 2209 and 2248 of NS5A of genotype 1b hepatitis C virus (HCV-1b) have been reported to be associated with the sensitivity to interferon-α (IFN-α). The present study was performed to analyze such relationship in Korean patients with chronic hepatitis C and HCV-1b (n=19),including 12 chronic hepatitis C patients treated with IFN-α, 3 chronic hepatitis C patients without treatment as controls, and 4 patients with hepatocellular carcinoma (HCC). Two serum samples, before and after the treatment, were analyzed for the mutations by reverse transcription-polymerase chain reaction, cloning and sequencing. The mutations were identified in 32% (6/19), including five intermediate type (1-3 mutations) and one mutant type (4 or more). In 12 patients treated with IFN-α, the number of amino acid substitutions in NS5A2209-2248 was not associated with outcome of the treatment.
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KEYWORD
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